The most significant challenge in trace element analysis of drinking water is ensuring detection capability that complies with the regulatory framework at the same time as maximizing sample throughput. The NexION® 1100 ICP-MS solves the challenges that high-throughout laboratories face using a robust, simple method and a single gas mixture. This application note explains how the NexION 1100 exceeds expectations on detection capability and details the benefits of using the single gas mixture for a wide range of elements, even those where the first ionization energy is relatively high (e.g. selenium).