QSight LC/MS/MS System | PerkinElmer
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QSight LC/MS/MS System

More than ever, laboratories analyzing food and environmental samples are faced with evolving challenges with stricter regulations demanding lower detection limits and higher levels of productivity. Lab operations need to be optimized, without any compromise on analysis confidence and accuracy.

With the PerkinElmer QSight® Triple Quad LC/MS/MS labs can test for the most challenging samples with maximized uptime and confidence. The unique dual-source configuration enables high-throughput labs to collect data in two complementary modes, maximizing the output from a single injection. Combined with the StayClean technology dramatically reduced source cleaning and maintenance, translating into higher productivity and high ROI. Running on the PerkinElmer Simplicity 3Q Software, the PerkinElmer QSight Triple Quad LC/MS/MS is easy-to-learn and use and it is a complete solution streamlining the complete workflow, from validated method development to data reporting.

Part Number
Model Name
BC003844
QSight 420 LC/MS/MS
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BC003382
QSight 220 LC/MS/MS
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BC003383
QSight 210 LC/MS/MS
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BC003265
QSight 110 LC/MS/MS
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Overview

The QSight LC/MS/MS System provides the capability and confidence required to analyze the most complex food and environmental samples. With high level of sensitivity and throughput, laboratories can meet even the most stringent regulatory requirements rapidly, easily, and effectively

  • Sensitivity for the most demanding regulations
  • Easy-to-use with ready to implement methods
  • Patented flow-based technology that enables up to 15% more productivity
  • StayClean Source, self-cleaning design for maximum sensitivity and exceptional uptime
  • Laminar Flow Ion Guide for highly efficient field-free transmission, providing virtually no maintenance requirements
  • Dual Source technology gives you the capability to set ESI or APCI modes, with two independent probes for true multiplexing
  • Modular Simplicity 3Q Software to acquire, quantify, and report with flexible data viewing options and powerful remote diagnostics.
  • Different models available (QSight 110 LC/MS/MS, QSight 210 LC/MS/MS, QSight 220 LC/MS/MS, QSight 420 LC/MS/MS) addressing different levels of performance and efficiency required by different labs’ analysis needs.

Specifications

Model Name QSight 220 LC/MS/MS
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Application Note

A Comparison Between ESI and APCI Ionisation Modes

Changing the source on many an LC/MS/MS instrument from ESI to APCI, and vice versa, involves cooling the source, manual removal and installation of the new source, followed by heating of the new source to the operating temperature, resulting in low throughput for analyses utilizing both ESI and APC ...

PDF 726 KB
A Multiclass Multiresidue Method for Analysis of Veterinary Drugs in Chicken by UHPLC/MS/MS

Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs ...

PDF 1 MB
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

PDF 1 MB
A Single Cannabis Method to Meet California Pesticide and Mycotoxin Residues Regulatory Requirements

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and ...

PDF 2 MB
Analysis of Acrylamide in Potato Chips by Isotopically Standard Addition UHPLC-MS/MS

Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and b ...

PDF 1 MB
Analysis of Aflatoxins by UHPLC

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

PDF 1 MB
Analysis of Benzo[a]pyrene in Tobacco and Related Products

Benzo[a]pyrene (B[a]P) is a well-known carcinogenic compound found in tobacco products and tobacco smoke. The Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) has recommended a gas chromatography/ mass spectrometry (GC/MS) method to determine concentrations of B[a]P in tobacc ...

PDF 582 KB
Analysis of Mycotoxins in Multi-Grain and Corn Cereals

Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum my ...

PDF 991 KB
Analysis of PPCPs in Drinking Water at Low PPT Levels by Online SPE-UHPLC-MS/MS

Pharmaceutical and Personal Care Products (PPCPs) are an emerging environmental concern, and include human and veterinary prescription and over-the-counter medications, sunscreens, lotions, soaps, and insect repellants. These commonly encountered products can enter the environment through various so ...

PDF 2 MB
Analysis of Pesticide Residues in Cannabis Regulated by Oregon State Using LC/MS/MS

Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues rel ...

PDF 1 MB
Analysis of Pork Adulterated Meat

A selective and sensitive LC/MS/MS method for fast identification and analysis of meat samples using three peptides specific for pork as biomarkers. . The optimized sample preparation procedure is easy to follow and can be used for analyzing raw, cooked and processed meat products. This method can s ...

PDF 1 MB
Analysis of Target Pesticide Residues in Berries with LC/MS/MS Coupled with a QuEChERS Sample Prep

Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS

PDF 1 MB
Analysis of illegal dyes in Chili Spices via UHPLC-MS/MS

Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no o ...

PDF 4 MB
Application Compendium - Analytical Solutions for Pesticides Analysis

The increasing demand for organic products, evolving global regulations, and improving accessibility of agricultural hubs to global markets results in pressure on food safety precautions. Translating, in part, to increased pesticide residue analysis demand. Mass spectrometry meets pesticide analysis ...

PDF 6 MB
Automated High Throughput Method for Analysis of Veterinary Drugs in Chicken by SPME-UHPLC/MS/MS

Veterinary drugs are utilized extensively in modern day farming to prevent and treat animal diseases. However, use of these drugs must be carefully monitored, and failure to regulate the presence of residual veterinary drugs in animal tissues could pose a risk to human health if animal tissues with ...

PDF 1 MB
Detection of Fipronil and Metabolites in Eggs by LC-MS/MS

Fipronil is a broad-spectrum phenylpyrazole insecticide almost used to protect corps from insects but also to treat lice and ticks in chickens. The U.S. EPA classified fipronil as Group C, possible human carcinogen, therefore International organizations defined admissible limits for the fipronil usa ...

PDF 719 KB
Determination of Coumarin in Electronic Cigarette Liquids by LC/MS/MS

Coumarin (1,2-benzopyrone) occurs as a natural component in some plants, and is utilized as a flavoring ingredient in some foods, tobaccos and cosmetic products. In recent years, coumarin has been added to electronic cigarette liquid nicotine solutions as a flavoring component, producing a complex f ...

PDF 2 MB
Determination of Mycotoxins in Cereals by LC/MS/MS with Online SPE

Mycotoxins are toxic secondary metabolites produced by fungi, and are capable of causing disease and death in both humans and animals. Sample preparation is a critical step in the successful analysis of mycotoxins in food matrices. The "dilute and shoot" approach is a quick and easy way to introduce ...

PDF 3 MB
Determination of Polycyclic Aromatic Hydrocarbons in Seafood by UHPLC- MS/MS

Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulati ...

PDF 1 MB
Determination of Thirteen Beta Agonists in Pork Using UHPLC - Tandem Mass Spectrometry

Beta-adrenergic receptor agonists (ß- agonists) are synthetic drugs utilized in the treatment of conditions such as asthma in humans, and are also used as a growth-promoting agent in food-producing animals. The use of ß- agonists in food-producing livestock has been either banned or regulated across ...

PDF 1 MB
Fast Screening 44 Illicit Drugs by UHPLC/MS/MS

Drugs of abuse, which can trigger the user’s central nervous system and induce an altered state of mind, can be divided into different types, including stimulants such as cocaine, psychoactive substances such as LSD (lysergic acid diethylamide) and marijuana, and painkillers such as morphine and her ...

PDF 1 MB
Free Amino Acid Analysis in Homogenized Tomato Using the QSight 220 LC/MS/MS

The free amino acid content of produce, such as tomatoes, has an impact on the nutritional value and flavor characteristics of the vegetable. In this application note, the efficient and effective transfer of a commercial laboratory's in-house method to a QSight 220 LC/MS/MS for amino acid determinat ...

PDF 1 MB
LC/MS/MS: Analysis of Alkylphenol Ethoxylates (APEO) And Alkylphenols (AP) In Textiles

Alkylphenol ethoxylates (APEOs) are common surfactants used in in industrial and consumer detergents and cleaners, as well plastics and many industrial applications. Nonylphenol ethoxylates (NPEOs) belong to the group of non-ionic surfactants and are of particular interest, as they tend to degrade t ...

PDF 2 MB
LC/MS/MS: Determination of Nitrosamines in Tobacco Products

Tobacco specific nitrosamines (TSNA) are a group of chemicals found in tobacco, smokeless tobacco, and tobacco smoke. They are widely considered to be among the most important arcinogens in tobacco products and cigarette smoke. Tobacco product manufacturers must report their contents in tobacco prod ...

PDF 2 MB
LC/MS/MS: Optimized Approach for the Analysis of Perfluoroalkyl and Polyfluoroalkyl Substances in Aqueous Samples by EPA Method 1633

Growing health concerns regarding PFAS and their prevalence in consumer goods and the environment indicate a critical need to execute existing and upcoming regulatory methods simply and reliably on commercially available instrumentation. The United States Environmental Protection Agency (EPA) has es ...

PDF 1 MB
Measurement of Cortisol & Cortisone in Urine

Simultaneous detect and quantify cortisol and cortisone in urine using the QSight 200 series mass spectrometer coupled with a commercially available kit.

PDF 615 KB
Measurement of Homovanillic Acid, Vanillylmandelic Acid & 5-HydroxyIndoleAcetic Acid in Urine

Discover a fast and reliable UHPLC-MS/MS method for the determination of HVA, VMA, and 5-HIAA acid in urine using the QSight 200 series mass spectrometer and a commercially available kit.

PDF 678 KB
Multi-residue Analysis of Pesticides in Animal Feed Using the QSight LC/MS/MS

Pesticides are employed in the growing of crops to prevent damage from a number of pests and fungi. When crops are grown to produce feed for livestock, there is a potential for pesticides residues to remain on the feeding stuffs, posing a risk to the livestock ingesting them. Pesticide residues are ...

PDF 2 MB
Multiclass-Multianalyte Method for Mycotoxin Testing in Foods Using Immunoaffinity Column Sample Clean-up with QSight LC/MS/MS

This work shows a reliable, sensitive and selective method for multi-mycotoxin determination in food samples using a PerkinElmer QSight 220 LC-MS/MS system. The method has been validated in eight different matrices and can be used in routine testing labs to meet regulatory requirements.

PDF 2 MB
Rapid Analysis of Haloacetic Acids in Drinking Water Using UHPLC/MS/MS

Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water, Which is known to be carcinogenic. The Japan Ministry of Health revised the inspection method for HAAs, which led to expansion of the analytical ...

PDF 1 MB
Rapid Determination of Trace Amounts of Aniline and Its Derivatives by Direct Injection UHPLC/MS/MS

Aniline and aniline derivatives are widely used as raw materials and intermediates in the polymer, rubber, dye, pesticide and pharmaceutical industries. Unintended releases of aniliane or its derivatives into the environment pose a serious threat, with release possible during any stage of production ...

PDF 587 KB
Simple and Sensitive Method for Determination of Ochratoxin A in Wine by LC/ MS Using QSight Technology

Ochratoxin A (OTA) is a secondary metabolite produced by Penicillium and Aspergillus fungi species found in soil and organic matter, and is one of the most widely reported of the nearly 400 recognized mycotoxin contaminants of agricultural products. OTA can enter the human food chain through contami ...

PDF 924 KB
Simultaneous Detection of Estrogenic and Progestogenic Hormones in Edible Bird's Nest

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

PDF 859 KB

Article

Driving Lab Efficiency and Performance Acceleration with LC/MS/MS

The COVID-19 pandemic impacted industries, economies, and lives, and brought about the need for a new approach for contract testing laboratories working in different application fields. Considering the directions shaping the laboratory industry, this article revises trends that could be also applied ...

PDF 438 KB
LC/MS/MS Basics: How It Works, Design Enhancements, and Key Applications

Liquid chromatography/tandem mass spectrometry (LC/MS/MS) is one of the most common bioanalytical methods used today, offering ultrasensitive detection in the several-partsper- million (or even parts-per-billion) range. The unique specificity of tandem mass spectrometry provides greater flexibility ...

PDF 1 MB

Brochure

Cannabis Testing Solutions Brochure

Whether your lab is well established or just starting up, having a single-source partner who can offer turnkey solutions that meet the current regulations is essential to a successful business. For years, we’ve worked with government and contract cannabis laboratories to develop industry-leading met ...

PDF 9 MB
Complete Aflatoxin M1 Testing Solutions

For third party food testing labs or producers who want to conduct aflatoxin M1 analysis in dairy products, our automated aflatoxin M1 ELISA assay and QSight LC/MS/MS aflatoxin M1 analyzer provide sensitive, accurate, and fit for purpose screening and confirmative analysis solutions that you can use ...

PDF 3 MB
Comprehensive Forensic Analysis Solutions

This brochure provides a simple guide to the analytical solutions and supporting services we provide for forensics and toxicology laboratories. We know it's not as simple as it seems in the movies, on television, or in the latest potboiler: forensic science is an exacting science, driven by the twin ...

PDF 1 MB
Comprehensive Testing Solutions for Feed Millers

Feed milling today is a complex business, and agribusinesses both large and small need to balance the nutritional and safety needs of livestock with availability of raw ingredients and their seasonality and variability. Add to that the valuable supplementation and medication that millers supply, and ...

PDF 3 MB
Meat and Seafood Testing Solutions

Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle. Our commitment ...

PDF 6 MB
QSight Pesticides Analyzer Brochure

Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeonin ...

PDF 9 MB

Case Study

PFAS Monitoring: How One Scientist is Thinking Ahead for the Environment

Predicting the long-term impact some substances have on human health and the environment is extremely difficult and in some instances we only become aware of certain substances and chemicals’ toxic impact after they have been widely used. Recently, PFAS (per- and polyfluoroalkyl substances) have bec ...

PDF 341 KB

Ebook

What's in Your Water? PFAS Analysis Explained

Over the past decade, awareness and concern about Per- and Polyfluoroalkyl Substances (PFAS) has grown and led to more in-depth analysis of these compounds and the effects that they can have on human health. Due to their inert nature, PFASs are persistent organic pollutants and have been found to ac ...

PDF 1 MB

Flyer

Drinking Water Analysis Webinar Series

Emerging contaminants include a variety of different chemical pollutants including pharmaceuticals, personal care products, endocrine disrupting compounds, per- and polyfluoroalkyl substances and others which pose a significant risk to human health. This series of drinking water analysis webinars wa ...

PDF 1 MB
QSight Triple Quad LCMSMS Series 400 Flyer

Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series.

PDF 3 MB

Guide

Tips for Launching a Modern Cannabis Testing Lab

Demand for cannabis testing services continues to climb as more US states and countries around the globe implement regulated adult-use markets. The cannabis testing sector in the US, like many facets of the cannabis industry, is challenged by the complexity of working with a federally illegal but st ...

PDF 285 KB

Product Note

PDF 890 KB
QSight Simplicity 3Q Software Suite

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

PDF 1 MB

Regulatory Compliance Certification

Technical Note

Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB

White Paper

Mitigation of PFAS in Drinking Water Through Analytical Innovation

Per- and polyfluoroalkyl substances (PFAS) have gained significant attention as an emerging environmental and safety threat in the United States. Since the 1940s, PFAS are ubiquitous in industrial usage due to their chemical stability, thermal stability, and high resistance to degradation. Bioaccumu ...

PDF 900 KB