QSight LC/MS/MS System

Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs ...

A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and ...

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

Due to the large number of pesticides potentially used in rice production, the use of multi-residue methods capable of determining many pesticides in one single run is the most efficient approach. In this study, a fast, sensitive and selective multiresidue method has been developed for analysis of o ...

Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum my ...

Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues rel ...

This application note details an online-SPE-LC/MS/MS method for the determination of polycyclic aromatic hydrocarbons (PAHs) in drinking water samples which reaches the low detection levels required by EU regulations. The method couples the SP50 UHPLC system to the QSight® 400 series triple-quad mas ...

Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS

In order to protect human health, regulatory agencies around the world have established maximum residue levels (MRLs) or tolerances of veterinary drugs in foods. The use of highly sensitive and selective techniques for accurate monitoring of tetracyclines based on regulatory requirements is essentia ...

Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowan ...

Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no o ...

With routine labs tasked with the analysis of larger and larger target lists, and with greater numbers of samples requiring analysis, we deployed simple sample preparation protocols such as solvent extraction to meet the need of high sample throughput with lower cost. In this work, we demonstrate ho ...

The increasing demand for organic products, evolving global regulations, and improving accessibility of agricultural hubs to global markets results in pressure on food safety precautions. Translating, in part, to increased pesticide residue analysis demand. Mass spectrometry meets pesticide analysis ...

In this study we show two methods for the analysis of over 30 antibiotics and veterinary drugs in milk regulated by the Food Safety and Standards Authority of India (FSSAI). For polar analyte analysis, such as aminoglycoside antibiotics (apramycin, spectinomycin, and neomycin) in milk, a mixed mode ...

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.

Glyphosate is a very polar compound with high solubility in water and low solubility in most organic solvents and, as such, requires methods based on derivatization which are labor-intensive and time consuming. The present work shows a 12 minute LC-MS/MS method with an amino-based column to analyze ...

Agricultural growing of hemp products for the purposes of cannabidiol (CBD) extraction was legalized in the United States with the passing of the Agricultural Improvement Act of 2018. Since the act passed, heightened concern over the use of pesticides in hemp production has been appreciated. However ...

Quantitative analysis of cell culture media components is a critical step in upstream bioprocess development. A comprehensive and quantitative understanding of cellular metabolic components could lead to a greater understanding of the process impacts on cell growth, productivity, and product quality ...

This application note outlines a new workflow with one instrument platform (LC/MS/MS) method that is ideal for simultaneous analysis of pesticide and mycotoxins residue in cannabis. This application note demonstrates the performance of a LC/MS/MS ESI and APCI method with a single solvent extraction ...

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals developed in the 1940s, and widely used for their surfactant properties. Due to their prevalent use within consumer products and persistence in nature, PFAS have leached into the air, soil, and water, making exposure wides ...

Tobacco specific nitrosamines (TSNA) are a group of chemicals found in tobacco, smokeless tobacco, and tobacco smoke. They are widely considered to be among the most important arcinogens in tobacco products and cigarette smoke. Tobacco product manufacturers must report their contents in tobacco prod ...

Growing health concerns regarding PFAS and their prevalence in consumer goods and the environment indicate a critical need to execute existing and upcoming regulatory methods simply and reliably on commercially available instrumentation. The United States Environmental Protection Agency (EPA) has es ...

Discover a fast and reliable UHPLC-MS/MS method for the determination of HVA, VMA, and 5-HIAA acid in urine using the QSight 200 series mass spectrometer and a commercially available kit.

Sensitive and accurate determination of remdesivir and GS-441524 in human plasma samples for pharmacokinetic and pharmacodynamic studies of remdevisir.

Following the 2018 legalization of recreational cannabis usage in Canada, the quality and safety of cannabis products has garnered significant attention. Health Canada has developed a regulatory program mandating pesticide testing on all cannabis products. Under the program, licensed producers (LPs) ...

The use of cannabis concentrates and CBD products (edibles, topicals, vape products, etc.) has increased in popularity as new regulation has been passed legalizing medicinal and recreational use in a number of states and provinces. Testing to ensure that pesticide and mycotoxin levels in cannabis pr ...

Cyanotoxins often exist intracellularly in cyanobacteria and are released into the water when cells die. Blooms caused by cyanobacteria can be harmful to the human health, animals, and the environment. Microcystin-LR (MC-LR) is one of the most common cyanotoxins and ingestion will cause negative hum ...

This application note describes a novel LC/MS/MS method with dual ESI and APCI source for analysis of different pesticides and mycotoxins residues regulated by seven different states in cannabis samples as of June 2021. The straightforward sample preparation procedure allows to achieve short sample ...

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic organic compounds which have been utilized as aqueous film forming foams (AFFF) for firefighting purposes, and as stain and water resistant coatings on a number of consumer products such as clothing, furniture or cookware. P ...

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

Wine can often contain pesticides and fungicides that have been sprayed on the fruits during their growing period. In addition to these contaminants, wine can also contain additives that have been deliberately added during production processes to improve its flavor and color. In this study, a simple ...

Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeonin ...

Over the past decade, awareness and concern about Per- and Polyfluoroalkyl Substances (PFAS) has grown and led to more in-depth analysis of these compounds and the effects that they can have on human health. Due to their inert nature, PFASs are persistent organic pollutants and have been found to ac ...

Demand for cannabis testing services continues to climb as more US states and countries around the globe implement regulated adult-use markets. The cannabis testing sector in the US, like many facets of the cannabis industry, is challenged by the complexity of working with a federally illegal but st ...

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

Product Certificate for the QSight 300/400 Series

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF