QSight Triple Quad LC-MS/MS 400 Series | PerkinElmer
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QSight LC/MS/MS System

More than ever, laboratories analyzing food and environmental samples are faced with evolving challenges with stricter regulations demanding lower detection limits and higher levels of productivity. Lab operations need to be optimized, without any compromise on analysis confidence and accuracy.

With the PerkinElmer QSight® Triple Quad LC/MS/MS labs can test for the most challenging samples with maximized uptime and confidence. The unique dual-source configuration enables high-throughput labs to collect data in two complementary modes, maximizing the output from a single injection. Combined with the StayClean technology dramatically reduced source cleaning and maintenance, translating into higher productivity and high ROI. Running on the PerkinElmer Simplicity 3Q Software, the PerkinElmer QSight Triple Quad LC/MS/MS is easy-to-learn and use and it is a complete solution streamlining the complete workflow, from validated method development to data reporting.

Part Number
Model Name
BC003844
QSight 420 LC/MS/MS
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BC003382
QSight 220 LC/MS/MS
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BC003383
QSight 210 LC/MS/MS
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BC003265
QSight 110 LC/MS/MS
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Overview

The QSight LC/MS/MS System provides the capability and confidence required to analyze the most complex food and environmental samples. With high level of sensitivity and throughput, laboratories can meet even the most stringent regulatory requirements rapidly, easily, and effectively

  • Sensitivity for the most demanding regulations
  • Easy-to-use with ready to implement methods
  • Patented flow-based technology that enables up to 15% more productivity
  • StayClean Source, self-cleaning design for maximum sensitivity and exceptional uptime
  • Laminar Flow Ion Guide for highly efficient field-free transmission, providing virtually no maintenance requirements
  • Dual Source technology gives you the capability to set ESI or APCI modes, with two independent probes for true multiplexing
  • Modular Simplicity 3Q Software to acquire, quantify, and report with flexible data viewing options and powerful remote diagnostics.
  • Different models available (QSight 110 LC/MS/MS, QSight 210 LC/MS/MS, QSight 220 LC/MS/MS, QSight 420 LC/MS/MS) addressing different levels of performance and efficiency required by different labs’ analysis needs.

Specifications

Model Name QSight 420 LC/MS/MS
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Application Note

A Multiclass Multiresidue Method for Analysis of Veterinary Drugs in Chicken by UHPLC/MS/MS

Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs ...

PDF 1 MB
A Simple and Sensitive Method for Rapid Determination of PFOA and PFOS in Water Samples by Direct Injection UHPLC/MS/MS

Per- and polyfluoroalkyl substances (PFASs), or Per- and polyfluorinated compounds (PFCs), represent a group of anthropogenic chemicals that have been produced and widely used in industrial applications and consumer products since the 1950s. The unique physical and chemical characteristics of these ...

PDF 1 MB
A Single Cannabis Method to Meet California Pesticide and Mycotoxin Residues Regulatory Requirements

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and ...

PDF 2 MB
Analysis of Acrylamide in Potato Chips by Isotopically Standard Addition UHPLC-MS/MS

Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and b ...

PDF 1 MB
Analysis of Aflatoxins by UHPLC

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

PDF 1 MB
Analysis of Challenging Polar Contaminants in Water by LC/MS/MS with Direct Injection

Several directives throughout the EU provide guidance on environmental quality standards for water, and define more than 30 priority substances as significant risk to humans. Many of the monitoring limits within these directives are set at low µg/L (ppb) levels, and as such, require highly sensitive ...

PDF 1 MB
Analysis of Low PPT Levels of Estrogens in Serum without Derivatization Using QSight 420 UHPLC/MS/MS System

Estrogens are steroid hormones derived from cholesterol. They are crucial for the development of female secondary sex characteristics and reproductive functions, and are also important for many other non–sex-specific processes, including growth, skeleton maintenance, cardioprotective, and neuroprote ...

PDF 1 MB
Analysis of Mycotoxins in Multi-Grain and Corn Cereals

Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum my ...

PDF 991 KB
Analysis of Per- and Polyfluoroalkyl Substances by EPA Method 8327 Using the QSight 220 UHPLC/MS/MS

Per- and polyfluoroalkyl substances (PFAS) are man-made carbon-chain based compounds that have been widely used in commercial and industrial products such as fire-fighting foams, water proofing treatments for clothing and furniture, nonstick cookware, and paper. PFAS’ are thermally and chemically st ...

PDF 1 MB
Analysis of Polycyclic Aromatic Hydrocarbons (PAHs) by Online SPE-LC/MS/MS in Drinking Water

This application note details an online-SPE-LC/MS/MS method for the determination of polycyclic aromatic hydrocarbons (PAHs) in drinking water samples which reaches the low detection levels required by EU regulations. The method couples the SP50 UHPLC system to the QSight® 400 series triple-quad mas ...

PDF 1 MB
Analysis of Target Pesticide Residues in Berries with LC/MS/MS Coupled with a QuEChERS Sample Prep

Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS

PDF 1 MB
Analysis of Tetracycline in Animal Tissue Using UHPLC/MS/MS System equipped with QS-works Autosampler

In order to protect human health, regulatory agencies around the world have established maximum residue levels (MRLs) or tolerances of veterinary drugs in foods. The use of highly sensitive and selective techniques for accurate monitoring of tetracyclines based on regulatory requirements is essentia ...

PDF 1 MB
Analysis of Water-Soluble Vitamins in Infant Formula by UHPLC-MS MS

Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowan ...

PDF 1 MB
Determination of Aflatoxin M1 in Milk and Infant Formula by QSight LC-MS-MS

Aflatoxin B1 is often found in animal feeds such as corn, cottonseed cake, groundnut meal, and other agricultural commodities. When these contaminated feeds are ingested by milk-producing animals, such as cattle, aflatoxin B1 can be converted to aflatoxin M1 (a hydroxy derivate of aflatoxin B1) by o ...

PDF 949 KB
Determination of Antibiotics and Veterinary Drugs in Milk by QSight LC/MS/MS

In this study we show two methods for the analysis of over 30 antibiotics and veterinary drugs in milk regulated by the Food Safety and Standards Authority of India (FSSAI). For polar analyte analysis, such as aminoglycoside antibiotics (apramycin, spectinomycin, and neomycin) in milk, a mixed mode ...

PDF 985 KB
Determination of Polycyclic Aromatic Hydrocarbons in Seafood by UHPLC- MS/MS

Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulati ...

PDF 1 MB
Determination of Sulfonamides in Honey

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.

PDF 1 MB
PDF 1 MB
Direct Analysis of Glyphosate and Similar Polar Pesticides in Oatmeal by UHPLC-MS/MS

Glyphosate is a very polar compound with high solubility in water and low solubility in most organic solvents and, as such, requires methods based on derivatization which are labor-intensive and time consuming. The present work shows a 12 minute LC-MS/MS method with an amino-based column to analyze ...

PDF 1 MB
Efficient LC/MS/MS Method for Testing Hemp Samples for Pesticide Residues

Agricultural growing of hemp products for the purposes of cannabidiol (CBD) extraction was legalized in the United States with the passing of the Agricultural Improvement Act of 2018. Since the act passed, heightened concern over the use of pesticides in hemp production has been appreciated. However ...

PDF 1 MB
Fast and Targeted Analysis of Cell Culture Media Components using QSight LC/MS/MS

Quantitative analysis of cell culture media components is a critical step in upstream bioprocess development. A comprehensive and quantitative understanding of cellular metabolic components could lead to a greater understanding of the process impacts on cell growth, productivity, and product quality ...

PDF 1 MB
LC/MS/MS Analytical Method for Pesticide Residue in Cannabis Flower as Defined by Florida Testing Requirements

This application note outlines a new workflow with one instrument platform (LC/MS/MS) method that is ideal for simultaneous analysis of pesticide and mycotoxins residue in cannabis. This application note demonstrates the performance of a LC/MS/MS ESI and APCI method with a single solvent extraction ...

PDF 2 MB
LC/MS/MS: Analysis of Alkylphenol Ethoxylates (APEO) And Alkylphenols (AP) In Textiles

Alkylphenol ethoxylates (APEOs) are common surfactants used in in industrial and consumer detergents and cleaners, as well plastics and many industrial applications. Nonylphenol ethoxylates (NPEOs) belong to the group of non-ionic surfactants and are of particular interest, as they tend to degrade t ...

PDF 2 MB
Meeting Canadian Cannabis Pesticide Residues Regulatory Requirements by LC/MS/MS

Following the 2018 legalization of recreational cannabis usage in Canada, the quality and safety of cannabis products has garnered significant attention. Health Canada has developed a regulatory program mandating pesticide testing on all cannabis products. Under the program, licensed producers (LPs) ...

PDF 1 MB
Method Validation for Atrazine Analysis in Fresh, Atypical Mineral and Carbonated Waters

EU water policies are reevaluated on a consistent basis to ensure water sources do not contain contaminants at levels above regulatory levels. As regulations are reviewed, regulatory limits are often lowered, and analytical techniques must adapt to meet the new stringent requirements. In this applic ...

PDF 1 MB
Polymer Applications Compendium

Today’s plastics are some of the most used materials on a global volume basis. Broadly integrated into today’s industrial and commercial lifestyles, they make a major, irreplaceable contribution to virtually every product category. In this compendium you will find a wide range of applications for po ...

PDF 57 MB
Quantitation of Microcystins and Nodularin in Drinking Water Samples to Meet EPA Method 544 Requirements Using QSight LC/MS/MS

Cyanotoxins often exist intracellularly in cyanobacteria and are released into the water when cells die. Blooms caused by cyanobacteria can be harmful to the human health, animals, and the environment. Microcystin-LR (MC-LR) is one of the most common cyanotoxins and ingestion will cause negative hum ...

PDF 901 KB
Quantitation of Pesticide and Mycotoxin Residues in Cannabis as Defined by Seven States Recreational Cannabis Regulations

This application note describes a novel LC/MS/MS method with dual ESI and APCI source for analysis of different pesticides and mycotoxins residues regulated by seven different states in cannabis samples as of June 2021. The straightforward sample preparation procedure allows to achieve short sample ...

PDF 777 KB
Rapid and Sensitive Analysis of 17 Per-and Polyfluoroalkyl Substances in Water by Direct Injection with QSight 420

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic organic compounds which have been utilized as aqueous film forming foams (AFFF) for firefighting purposes, and as stain and water resistant coatings on a number of consumer products such as clothing, furniture or cookware. P ...

PDF 3 MB
Simultaneous Detection of Estrogenic and Progestogenic Hormones in Edible Bird's Nest

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

PDF 859 KB
Simultaneous Determination of Plant Growth Regulators in Bean Sprouts

A simple and sensitive method for the simultaneous determination of plant growth regulators

PDF 2 MB
“No Dilute” Just Shoot: Robustness of a QSight LC-ESI-MS/MS for Low Level Pesticide Residue Analysis in Wine

In this study, the QSight LC-MS/MS system was used to evaluate the potential of eliminating sample preparation for trace level pesticide analysis in a complex sample such as wine. We injected undiluted red and white wine samples into the mass spectrometer and studied reproducibility in analysis of t ...

PDF 962 KB

Article

Driving Lab Efficiency and Performance Acceleration with LC/MS/MS

The COVID-19 pandemic impacted industries, economies, and lives, and brought about the need for a new approach for contract testing laboratories working in different application fields. Considering the directions shaping the laboratory industry, this article revises trends that could be also applied ...

PDF 438 KB

Brochure

Productivity to the Power of Two - QSight LC/MS/MS System Brochure

When analyzing food and environmental samples, laboratories often need multiple system to get the qualitative and quantitative information on contaminants. But this can result in duplicated sample preparation processes, increased cost of ownership – and suboptimal lab efficiency. Discover the unique ...

PDF 3 MB

Ebook

What's in Your Water? PFAS Analysis Explained

Over the past decade, awareness and concern about Per- and Polyfluoroalkyl Substances (PFAS) has grown and led to more in-depth analysis of these compounds and the effects that they can have on human health. Due to their inert nature, PFASs are persistent organic pollutants and have been found to ac ...

PDF 1 MB

Poster

Advanced Solutions for Polymers and Plastics

This poster lays out our whole material characterization range for the analysis of polymers and plastics. Find ideal techniques and instruments at each stage in the polymer manufacturing process: Resin Development - Resin Manufacture - Compound Development - Compound Manufacture - Product Forming - ...

PDF 2 MB
Infographic - Solutions for your Toxicology Lab

Infographic Poster showing the range of different analytical solutions for Toxicology Labs; from GC and LC, to ICP-MS and UV-Vis. Benchtop and floor standing chromatography, spectroscopy and thermal solutions for everyday robust and reliable analyses. FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC ...

PDF 460 KB

Product Note

QSight Simplicity 3Q Software Suite

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

PDF 1 MB
QSight Triple Quadrupole LC/MS/MS Preparing Your Lab

Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements

PDF 660 KB

Regulatory Compliance Certification

Product Certificate - QSight 300/400 Series

Product Certificate for the QSight 300/400 Series

PDF 135 KB

Technical Note

Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB
Theoretical Studies of Swirling Flow and Heating Methods

Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial

PDF 503 KB

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